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Welcome to the forum Doug !
glad to have you aboard.

The Echophone cathedral is a goregous radio as I recall, I hope you get this sorted out.
I didn’t know if you are an avid collector so forgive me if this is too basic.

– the 280 is a rectifier. the first number relates to the manufacturer so you may also find 280 or 380, perhaps others. it is an 80 electronically. an 80 is probably the most common rectifier for radios this age. a tube designated 80 is more common and will have the ST envelope (coke bottle shape) you will probably pay less for an 80 than a 280 because of it’s scarcity. the difference is wheather you see the pretty globes in the back of the set.

227 or 27 same thing, 227 is a globe 27 an ST. this is a pretty easy to get tube. some TRF radios had a bunch of them so they seem more common than the others you want.

The 245’s – or 45’s are expensive. There has been a trend with custom amplifier builders to drive the prices up on these. The danger here is that most of the beautiful cabinet radios made about 1929 use these tubes, so this activity is a thorn in the side of those who would like to see every remaining set restored and working. this tube is not that uncommon and you will find them.

If I moved that radio. I would be sure to remove those globe 245’s to prevent breakage, hopefully they put them in another box for safekeeping ?

So when you find a source, you will have a choice of either more expensive but beautiful globe tubes or ST shaped tubes which will perform just as well if you aren’t concerned about the cosmetics or if you play the radio a lot. There are some tube dealers that you could buy them from , hopefully someone local can assist.